MOLEKULAR DOCKING AKTIVITAS SENYAWA ANTI KANKER ALAMI TERHADAP KANKER SERVIKS DARI BEBERAPA TANAMAN OBAT: LITERATUR REVIEW

Abstract

Cervical cancer is one type of cancer with a high incidence and mortality rate, especially in developing countries. Current treatments for cervical cancer still face various limitations, so new approaches are needed, including the exploration of natural bioactive compounds from medicinal plants. Molecular docking is a computational method used to simulate the interaction between ligand molecules and target proteins, so it can be used to evaluate the potential of anti-cancer compounds in silico. This study aims to assess the molecular docking activity of natural anti-cancer compounds against cervical cancer through literature review. This study uses the literature review method by analyzing 30 articles published in the 2016-2024 time span, which are obtained from various databases such as Google Scholar, PubMed, Scopus, and others. The results showed that various bioactive compounds such as Forskolin, Stigmasterol, Gnetin C, Longipinocarvone, Eleutherinoside A, Epicatechin Gallate, Myricetin, and Quercetin have significant anticancer activity against cervical cancer protein targets, including E6, E7, FN1, IL-10, MAPK3, and caspase-8 proteins. Binding affinity values, interaction stability, and pharmacokinetic analysis indicate that the compounds have the potential to be developed as therapeutic agents for cervical cancer. Cervical cancer is one type of cancer with a high incidence and mortality rate, especially in developing countries. Current treatments for cervical cancer still face various limitations, so new approaches are needed, including the exploration of natural bioactive compounds from medicinal plants. Molecular docking is a computational method used to simulate the interaction between ligand molecules and target proteins, so it can be used to evaluate the potential of anti-cancer compounds in silico. This study aims to assess the molecular docking activity of natural anti-cancer compounds against cervical cancer through literature review. The molecular docking results show great potential, further validation through in vitro, in vivo, and clinical testing is needed to ensure the effectiveness and safety of these compounds. This study underscores the importance of exploring natural compounds from medicinal plants as candidates for effective cervical cancer therapy.